姓名:蘇聯麟
職稱:副教授、碩士生導師
E-mail:sll2020@njucm.edu.cn
主要研究方向:中藥炮制機理與質量标準研究
個人簡介
蘇聯麟,博士,副教授,民進會員。bevictor伟德官网中藥炮制教研室骨幹教師,華潤三九博士後;中華中醫藥學會中藥炮制分會青年委員,世界中醫藥聯合會中藥飲片質量專業委員會理事,江蘇省藥學會中藥藥理專業委員會委員等。主要從事中藥炮制機理及質量标準研究,包括中藥質量标志物、代謝組學、腸道微生物組等。在國内外高水平期刊上發表論文50餘篇,其中以第一/通訊作者于Food Chemistry等期刊發表高水平論文20餘篇。擔任Frontiers in Cellular and Infection Microbiology期刊專欄客座編委,STCM青年編委等。主持“國家自然科學青年基金項目”1項、省高校自然科學基金1項、企業委托課題1項及其他橫向課題5項;主持安徽省博後基金1項;參與國家自然科學基金項目8項,其中國自然重點項目1項;參與國家重點研發計劃(2018、2023年)2項,申請并獲授權發明專利4項。
承擔的主要科研項目
(1)國家自然科學基金委員會青年科學基金項目(82304723),基于糖組學及“粘蛋白O-聚糖/PRRs”雙調控模式的五味子醋制增強澀腸止瀉作用機制研究,2024-01-01 至 2026-12-31,主持,30萬元,在研;
(2)(2)江蘇省高等學校 基礎科學(自然科學)研究面上項目(23KJB360008),基于“CAZymes-SCFAs-黏膜免疫”軸探究五味子醋制增強澀腸止瀉作用機制,2023.7 至2025.7,主持,3萬元,在研;
(3)華潤三九醫藥股份有限公司,企業委托,4個配方顆粒制備工藝和标準研究,2021-08 至 2023-08,主持,76萬元,結題;
(4)中國生物技術發展中心,國家重點研發計劃,2023YFC3504200,中藥飲片炒炙智能識别與生産控制技術研究,2023-11 至 2026-10,參與,2418.88萬元,在研;
(5)國家自然科學基金委員會面上項目(82274241),從“豆豉後下”實現殺酶保苷/保肽的角度探讨栀子豉湯抗抑郁作用機制,2023-01-01 至 2026-12-31,參與,51萬元,在研;
(6)國家自然科學基金委員會面上項目(82274096),基于生栀子瀉溫邪實火、炒栀子清郁熱與膿毒症雙向免疫調節特點探索栀子炮制機理與合理用藥,2023-01-01 至 2026-12-31,參與,52萬元,在研;
(7)國家自然科學基金委員會面上項目(82173975)基于整合證據鍊的郁金醋制增強疏肝止痛作用機制研究,2022-01-01 至 2025-12-31,參與,55萬元,在研;
(8)國家自然科學基金委員會重點項目(82130116)蒙藥巴格-塔日努(京大戟)等3種大戟屬常用有毒藥炮制減毒增效的共性機制研究,2022-01-01 至 2026-12-31,參與,290萬元,在研;
(9)國家自然科學基金委員會面上項目(82074004),DASS-RTCA系統驅動“物質-效應-标準”三元關聯的經典名方制劑當歸補血湯的質量一緻性評價研究,2021-01-01 至 2024-12-31,參與,55萬元,結題;
(10)國家自然科學基金委員會,面上項目,81873008,基于腸道菌群介導的五味子醋制增強收斂止瀉效應機制研究,2019-01-01 至 2022-12-31,參與,59萬元,結題。
代表性論文
Zhang J, Gao T, Chen G, Liang Y, Nie X, Gu W, Li L, Tong H, Huang W, Lu T, Bian Z, Su L. Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism. Phytomedicine, 2024, 135: 156057.(中科院一區,IF:6.7)
Lian-lin Su1; Xiaoman Li1; Zhi-jun Guo; Xiao-yan Xiao; Peng Chen; Jiu-ba Zhang; Chun-qin Mao; De Ji; Jing Mao; Bo Gao*; Tu-lin Lu*; Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide, Journal of Ethnopharmacology, 2023, 310: 116351. (中科院二區,IF:5.4)
Su L#; Mao C#; Wang X; Li L; Tong H; Mao J; Ji D*; Lu T*; Hao M; Huang Z; The anti-colitis effect of Schisandra chinensis polysaccharide is associated with the regulation of the composition and metabolism of gut microbiota, Frontiers in Cellular and Infection Microbiology, 2020,10: 519479.(中科院二區,IF:6.1)
Lianlin Su#; Jing Mao#; Min Hao; Tulin Lu*; Chunqin Mao*; De Ji; Huangjin Tong; Chenghao Fei; Integrated Plasma and Bile Metabolomics Based on an UHPLC-Q/TOF-MS and Network Pharmacology Approach to Explore the Potential Mechanism of Schisandra chinensis-Protection from Acute Alcoholic Liver Injury, Frontiers in pharmacology, 2020,10:1543.(中科院二區,IF:5.8)
Jiu-ba Zhang1; Bin Wang1; Yun-fei Zhang1; Yi Wu; Mingxuan Li; Ting Gao; Tu-lin Lu*; Zhen-hua Bian*; Lian-lin Su*; E-eye and FT-NIR combined with multivariate algorithms to rapidly evaluate the dynamic changes in the quality of Gastrodia elata during steaming process, Food Chemistry, 2024, 439:138148.(中科院一區,IF:8.8)
YuLi#;ChenghaoFei#; ChunqinMao; DeJi; JingwenGong; YuwenQin; LingyunQu; WeiZhang; ZhenhuaBian; LianlinSu*; TulinLu*; Physicochemical parameters combined flash GC e-nose and artificial neural network for quality and volatile characterization of vinegar with different brewing techniques, Food Chemistry, 2022, 374: 131658.(中科院一區,IF:9.2)
Lianlin Su† , Huangjin Tong† , Jiuba Zhang, Min Hao, Chenghao Fei, De Ji, Wei Gu, Zhenhua Bian, Chunqin Mao*, Tulin Lu*; Revealing the mechanism of raw and vinegar-processed Curcuma aromatica Salisb. [Zingiberaceae] regulates primary dysmenorrhea in rats via integrated metabolomics, Frontiers in pharmacology, 2022, 13:926291.(中科院二區,IF:5.98)
Tian Y, Shen X, Hu T, Liang Z, Ding Y, Dai H, Liu X, Lu T, Yin F, Shu Y, Guo Z, Su L*, Li L*. Structural analysis and blood-enriching effects comparison based on biological potency of Angelica sinensis polysaccharides. Front Pharmacol, 2024, 15: 1405342.(中科院二區,IF:4.4)
Chen P, Fei C, Fu R, Xiao X, Qin Y, Li X, Guo Z, Huang J, Ji D, Li L, Lu T*, Guo Q*, Su L*. Polygonati Rhizoma varieties and origins traceability based on multivariate data fusion combined with an artificial intelligence classification algorithm. Food chemistry, 2024, 460(Pt 1): 140350.(中科院一區,IF:8.8)
Xiao-yan Xiao #, Zhi-jun Guo #, Xiaoman Li, Peng Chen, Yu Li, Jiu-ba Zhang, Chun-qin Mao, De Ji, Lian-lin Su *, Bo Gao *, Tu-lin Lu *. Effects of wine processed Polygonatum polysaccharides on immunomodulatory effects and intestinal microecology in mice. Quality Assurance and Safety of Crops & Foods, 2023, 15(2): 161-174.(中科院三區,IF:4.4)
獲得獎項與榮譽
1.世界中聯中藥飲片質量專委會優秀教學成果二等獎(2023年,1/4);
2.蘇州市中西醫結合學會中西醫結合醫學科學技術将二等獎(2024年,5/6)。
其他成果
一、專利
(1)陸兔林,毛春芹,婁悅,毛靖,趙曉莉,許金國,蘇聯麟,梅茜,皮文霞,蘇雪蓉.一種鼈血晶及其制備方法和應用[P].ZL202211087679.3, 2023-08-08.
(2)陸兔林,毛春芹,徐祯,毛靖,蘇聯麟,李林,顧薇,季德,張科衛,王巧晗.一種能提高抗氧化活性的栀子花複合提取物及其應用[P].ZL202110577891.7,2023-01-31.
(3)毛春芹,陸兔林,費程浩,梅茜,蘇聯麟,季德,毛靖,顧薇,李昱,秦宇雯,李林,董佳佳.一種莪術提取物及其在制備防治冠心病藥物中的應用[P].ZL202210507145.5,2023-12-26.
(4)陸兔林,蘇聯麟,毛春芹,季德,顧薇,李昱,王巧晗,毛靖.五味子多糖在制備治療炎症性腸病藥物或保健品中的應用[P].ZL202010428961.8,2021-08-17.
二、論著
(1)《便秘中西醫診療實踐》,中國協和醫科大學出版社,2018,編委。