姓名:劉睿
職稱:教授、博士生導師
E-mail:liurui@njucm.edu.cn
主要研究方向:海洋藥用生物資源研究與開發、中藥動物藥資源化學
個人簡介
中國藥科大學博士,University of Wisconsin-Madison訪問學者,中國海洋學會海洋中藥專業委員會委員,中華中醫藥學會中藥資源分會青年委員,江蘇省海洋藥物專業委員會副秘書長。《中國現代中藥》編委,《Journal of Pharmaceutical Analysis》、《Science of Traditional Chinese Medicine》、《中草藥》、《中國藥科大學學報》、《中國現代應用藥學》、《bevictor伟德官网學報》等期刊青年編委。教育部第二批“全國高校黃大年式教師團隊”成員,入選中華中醫藥學會“青年人才托舉工程”,江蘇高校“青藍工程”中青年學術帶頭人培養對象,江蘇省“333高層次人才培養工程”第三層次培養對象。主持國家自然科學基金3項,部省級科研項目多項。近年來以通訊作者或第一作者在國内外學術刊物包括Advanced Functional Materials,Journal of Hazardous Materials,Analytical Chemistry,Food Chemistry等發表論文80餘篇。以第一發明人獲國家授權發明專利20餘件、PCT專利2件(美國、英國)。獲江蘇省科學技術二等獎,國家海洋科學技術獎二等獎。
承擔的主要科研項目
國家自然科學基金面上項目(82474055),硫巯基化修飾介導的水牛角藥效物質活化及其清熱功效作用機制研究,2025/01-2028/12,主持,在研。
國家自然科學基金面上項目(81973450),基于“腦-腸軸”研究水牛角含巯基肽類物質産生清熱/鎮靜功效的化學生物學機制,2020/01-2023/12,主持,結題。
國家自然科學基金青年基金(81202861),水牛角對發熱生物标記物的幹預及其效應物質基礎研究,2013/01-2015/12,主持,結題。
江蘇省自然科學基金面上項目(BK20241913),基于“QTRP-蛋白修飾譜”的水牛角活性硫基團作用靶點發現及其清熱功效機制研究,2024/07/01-2027/06/30,主持,在研。
江蘇現代農業産業單項技術研發項目(CX(22)3173),魚鱗、魚骨來源膠原肽的磷酸化、糖基化修飾關鍵技術研究及産品開發,2021/07-2024/06,主持,結題。
舟山科技局重大科技攻關項目(2023C13020),海洋源功效化妝品新原料開發應用研究,2023/10-2026/09,主持,在研。
代表性論文
Wei YQ*, Ju MM, Zheng F, Wei S, Han SY, Lu SF, Liu R*, Wu H*.Cuttlebone-derived organic matrix: a facile periosteum substitute for bone regeneration. Advanced Functional Materials, 2023, 33(31): 2214095. (IF = 18.5)
Zheng BR, Shang J, Wei YQ, Tao QQ, Yin JZ, Kang A, Liu R*, Lian HZ*, Han SY*. Chemoproteomic profiling by bioorthogonal probes to reveal the novel targets of acrylamide in microglia. Journal of Hazardous Materials, 2025, 484(15): 136760. (IF = 12.2)
Han SY, Li ZH, Shi YT, Cui YS, Huang JF, Frost DC, Rey FE, Liu R*, Li LJ*. 11-plex DiLeu isobaric labeling enables quantitative assessment of brain region protein-association networks impacted by the gut microbiome. Analytical Chemistry, 2024, 96(9): 3870-3878. (IF = 6.8)
Liu R, Wei PL, Keller C, Orefice N, Shi YT, Li ZH, Huang JF, Cui YS, Frost, D, Han SY, Cross TW, Rey F, Li LJ*. Integrated label-free and 10-plex DiLeu isobaric tag quantitative methods for profiling changes in the mouse hypothalamic neuropeptidome and proteome: assessment of the impact of the gut microbiome. Analytical Chemistry, 2020, 92(20): 14021-14030. (IF = 6.8)
Xia HR, Liu X, Cai S, Chen SJ, Li S, Zhao M, Duan JA, Liu R*, Han SY*. Identification and application of species-specific peptide biomarkers from soft-shelled turtles (Pelodiscus sinensis) using post-translational modification detection-based peptidomics analysis. Food Chemistry, 2023, 419: 135983. (IF = 8.5)
Han SY, Yan ZY, Huang XZ, Cai S, Zhao M, Zheng YF, Liu X, Xu HK, Xie Y, Hou R, Duan JA*, Liu R*. Response boosting-based approach for absolute quantification of gelatin peptides using LC-MS/MS. Food Chemistry, 2022, 390: 133111. (IF = 8.5)
Han SY, Zhao KX, Cai S, Jiang MT, Huang XZ, Chen SJ, Li S, Zhao M, Duan JA*, Liu R*. Discovery of peptide biomarkers by label-free peptidomics for discrimination of horn gelatin and hide gelatin from Cervus nippon Temminck. Food Chemistry, 2021, 363: 130347. (IF = 8.5)
Zheng F, Ju MM, Lü YJ, Hua YQ, Yao WF, Wu H, Zhao M, Han SY, Wei YQ*, Liu R*. Carp scales derived double cross-linking hydrogels achieve collagen peptides sustained-released for bone regeneration. International Journal of Biological Macromolecules, 2024, 255, 128276. (IF = 7.7)
Wu WX, Tang JY, Bao WL, Feng QY, Zheng J, Hong M, Guo S, Zhu Y, Huang SY, Zhao M, Duan JA*, Liu R*. Thiols-rich peptide from water buffalo horn keratin alleviates oxidative stress and inflammation through co-regulating Nrf2/Hmox-1 and NF-κB signaling pathway. Free Radical Biology and Medicine, 2024, 223: 131-143. (IF = 7.1)
Liu R, Huang Y, Xu HK, Zheng YF, Liu Y, Han SY, Yang M, Xie Y, Wang KX, Duan JA, Li LJ*. A strategy for identifying species-specific peptide biomarkers in deer-hide gelatin using untargeted and targeted mass spectrometry approaches. Analytica Chimica Acta, 2019, 1092: 32-41. (IF = 5.7)